I am a postdoctoral associate in the research group of Mark Johnson at Yale University. My current work focuses on using high-resolution mass spectrometry coupled to cold ion processing techniques and infrared photofragmentation spectroscopy to characterize the structures of ion-binding complexes and fragile catalytic intermediates. This is an exciting approach because it allows the interrogation of species which cannot otherwise be isolated, and because the technique probes molecules at low temperatures near their structural minima, where results from electronic structure calculation can most accurately be applied.
- Integration of high resolution mass spectrometry with cryogenic ion vibrational spectroscopy (In preparation)
From Oct 2015 to Oct 2018, I was a postdoctoral fellow in the research group of Carlos Baiz at the University of Texas - Austin. My work in Professor Baiz's group exploited computational modeling and ultrafast 2D IR spectroscopy to interrogate the conformational dynamics and energy exchange characteristics of calcium-binding proteins. 2D IR's strength lies in its extreme (picosecond) temporal resolution, which permits the direct investigation of solvation processes and structural fluctuations which are too fast to probe with other methods. Similarly, 2D IR allows the measurement of vibrational energy flow throughout a molecule.
- Non-additive effects of binding site mutations in calmodulin (Submitted)
- Vibrational relaxation in EDTA is ion-dependent (J. Phys. Chem. A 2018)
- Coordination to lanthanide ions distorts binding site conformation in calmodulin (PNAS 2018)
- An empirical IR frequency map for ester C=O stretching vibrations (J. Phys. Chem. A 2016)
I completed my Ph.D. (physical chemistry) at Princeton University in the research group of Steven Bernasek. My Ph.D. research explored the dynamics of heterogeneous oxidation reactions of platinum. In this work, I used high resolution tunable diode laser spectroscopy to measure the rotational-vibrational state population of reaction-produced CO2, thus inferring the likely geometry of its final surface-bound transition states. This technique is exceptional for its ability to resolve and measure the population of single rotational-vibrational quantum states, thus allowing the measurement of the "vibrational temperatures" which describe each of a molecule's normal vibrational modes.
- The internal energy of CO2 produced by catalytic oxidation of acetaldehyde on polycrystalline platinum (In preparation)
I went to college at the University of Virginia, where I graduated in 2009. As an undergraduate, I studied abroad in Paris, France during the fall of 2006 and worked in the lab of John T. Yates, Junior as an undergraduate researcher.
- A study of stabilization of P3HT/PCBM organic solar cells by photochemical active TiOx layer (Sol. Energ. Mat. Sol. Cells 2011)
- Enhancement of adsorption inside single-walled carbon nanotubes: Li doping effect on n-heptane van der Waals bonding (J. Phys. Chem. C 2009)